project4 Afbeelding7
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Identification of novel (genetic) determinants and pathways modulating cardiac arrhythmias

To identify novel (genetic) determinants and modifiers of cardiac electrophysiology in an unbiased way, we apply genetical genomics approaches incorporating large-scale electrophysiological phenotyping in rodents and human genome wide association studies with systems biology and proteomics. Identified genes of interest are subsequently studied for functional relevance using transgenic models and human induced pluripotent stem-cell derived cardiomyocytes (hiPSC-CMs).

Group members

Carol Ann Remme

Group Leader, PI

Vincent Portero

Post Doc

Simona Casini

Post Doc

Giovanna Nasilli

PhD Student

Gerard Marchal

PhD Student